Судубрилимаб
SudubrilimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2387417-06-1
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], monoclonal antibody;
gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV3-23*04 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03v G1m3>G1m17, nG1m1 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 N84.4>A (298) (232-341), CH3 E12 (357), M14 (359) (342-446), CHS K>del (447)) (119-447)], (221-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (90.0%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, non-glycosylated
gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV3-23*04 (85.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03v G1m3>G1m17, nG1m1 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 N84.4>A (298) (232-341), CH3 E12 (357), M14 (359) (342-446), CHS K>del (447)) (119-447)], (221-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (90.0%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, non-glycosylated
Структура
Иностранные названия
- Sudubrilimabum (латинское)
- Sudubrilimab (английское)
- Sudubrilimab (немецкое)
- Sudubrilimab (французское)
- Sudubrilimab (испанское)
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