Сурабген ломпарвовек

Rec. INN (наименование, зарегистрированное ВОЗ)

2374935-18-7

recombinant, non-replicating adeno-associated virus serotype 8 (rAAV8) vector encoding a soluble humanised anti-vascular endothelial growth factor (VEGF) antibody fragment (Fab) under control of a hybrid cytomegalovirus (CMV) immediate-early enhancer/chicken β-actin promoter, enhanced by a chicken β-actin intron and terminated by a rabbit β- globin polyadenylation signal. The heavy and light chains of the Fab are separated by a self-cleaving furin /F2A linker and the transgene is flanked by adeno-associated virus 2 (AAV2) inverted terminal repeats (ITRs)

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