Сурзебиклимаб
SurzebiclimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16669
CAS
2342597-90-2
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens HAVCR2 (hepatitis A virus cellular receptor 2, T-cell immunoglobulin mucin family member 3, Tim-3, TIM3, TIMD3, CD366)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-23*04 (93.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.7.13] (26-33.51-57.96-108) (1-119) -Homo sapiens IGHG1*01, G1m17,1, G1v4 CH2 A114 (CH1 K120 (217) (120-217), hinge 1-15 (218-232), linker (233-237), CH2 P114>A (330) (238-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (120-448)], (222-218')-disulfide with kappa light chain (1’-218’) [V-KAPPA (Homo sapiens IGKV3-15*01 (84%) -IGKJ4*01 (100%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'-111') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-23*04 (93.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.7.13] (26-33.51-57.96-108) (1-119) -Homo sapiens IGHG1*01, G1m17,1, G1v4 CH2 A114 (CH1 K120 (217) (120-217), hinge 1-15 (218-232), linker (233-237), CH2 P114>A (330) (238-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (120-448)], (222-218')-disulfide with kappa light chain (1’-218’) [V-KAPPA (Homo sapiens IGKV3-15*01 (84%) -IGKJ4*01 (100%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'-111') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Surzebiclimabum (латинское)
- Surzebiclimab (английское)
- Surzebiclimab (немецкое)
- Surzébiclimab (французское)
- Surzebiclimab (испанское)
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