Табирафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2839527-15-8

human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment containing immunoglobulin-like extracellular domain 2 (103- 206, 1-104 in the current sequence) fused to a human vascular endothelial growth factor receptor 2 (VEGFR-2) fragment containing immunoglobulin-like extracellular domain 3 (208-308, 105-205 in the current sequence) fused via peptide linker ²⁰⁶GGGGSGGGGS²¹⁵ to the gamma 1 heavy chain of anti-[human interleukin 6 (IL-6)] (216-664) [VH (Homo sapiens IGHV3-23*03 -(IGHD) - IGHJ3*02, CDR-Kabat [5.17.10] (246-250.265-281.314-323)) (216-334) -Homo sapiens IGHG1*03 R431>K (CH1 (335-432), hinge (433-447), CH2 L⁴⁵¹>A, L⁴⁵²>A, G⁴⁵⁴>A (448-557), CH3 L660>C (558-662), CHS (663-664)) (433-664)], (437-213')-disulfide with kappa light chain anti-[human interleukin 6 (IL- 6)] (1'-213') [V-KAPPA (Homo sapiens IGKV1-13*02 - IGKJ1*01, CDR-Kabat [10.7.9] (24'-33'.49'-55'.88'-96')) (1'- 106') -Homo sapiens IGKC*01 (107'-213')]; dimer (443- 443'':446-446'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa;

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