Табирафусп альфа тедромер

Prop. INN (наименование, предложенное ВОЗ)

2839527-16-9

human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment containing immunoglobulin-like extracellular domain 2 (103-206, 1-104 in the current sequence) fused to a human vascular endothelial growth factor receptor 2 (VEGFR-2) fragment containing immunoglobulin-like extracellular domain 3 (208-308, 105-205 in the current sequence) fused via peptide linker ²⁰⁶GGGGSGGGGS²¹⁵ to the gamma 1 heavy chain of anti-[human interleukin 6 (IL-6)] (216-664) [VH (Homo sapiens IGHV3-23*03 - (IGHD) -IGHJ3*02, CDR-Kabat [5.17.10] (246-250.265-281.314- 323)) (216-334) -Homo sapiens IGHG1*03 R⁴³¹>K (CH1 (335-432), hinge (433-447), CH2 L⁴⁵¹>A, L⁴⁵²>A, G⁴⁵⁴>A (448-557), CH3 L⁶⁶⁰>C (558-662), CHS (663-664)) (433-664)], (437-213')-disulfide with kappa light chain anti-[human interleukin 6 (IL-6)] (1'-213') [V-KAPPA (Homo sapiens IGKV1-13*02 -IGKJ1*01, CDR-Kabat [10.7.9] (24'-33'.49'-55'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dimer (443-443'':446-446'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa;
substituted at an average of one sulfur atom of cysteine residues 660 and 660'' with (3RS)-1-[1,1,1-tris({3-[2-(2,2,2-tris{[(2-{α- (bromo/ethoxy/hydro/hydroxy)poly[1-(10,10-dimethyl-6-oxido-6- oxo-2,5,7-trioxa-10-aza-6λ⁵-phosphaundecan-10-ium-1-oyl)-1- methylethane-1,2-diyl]-ω-yl}-2- methylpropanoyl)oxy]methyl}ethoxy)acetamido]propanamido}meth yl)-16,32-dioxo-3,6,9,12,19,22,25,28-octaoxa-15,31- diazatetratriacontan-34-yl]-2,5-dioxopyrrolidin-3-yl (tedromer)

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