Табитуксимаб барзуксетан

Rec. INN (наименование, зарегистрированное ВОЗ)

1612758-88-9

immunoglobulin G1-kappa, anti-[Homo sapiens FZD10 (frizzled class receptor 10, frizzled family receptor 10, Frizzled-10, CD350)], chimeric monoclonal antibody conjugated to barzuxetan, a DPTA chelator derivative;
gamma1 heavy chain chimeric (1-448) [Mus musculus VH (IGHV14-3*02 (99.0%) -(IGHD) -IGHJ3*01 (100%)) [8.8.11] (1- 118) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (215) (119-216), hinge (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-214')- disulfide with kappa light chain chimeric (1'-214') [Mus musculus V-KAPPA (IGKV12-46*01 (98.9%) -IGKJ2*01 (100%)) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')- bisdisulfide; conjugated, on an average of 2 to 4 lysyl, to barzuxetan, p-SCN-Bn-CHX-A"-DPTA, a DPTA chelator derivative

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