Тагитанлимаб
TagitanlimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2417649-97-7
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, B7H1, B7-H1, PDL1, PD-L1, PDCD1L1, B7 homolog 1)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV4-4*08 (81.4%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.7.14] (26-33.51-57.96-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), G1>A (240) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV6-21*02 (86.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-DG44 cell line, glycoform alfa
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV4-4*08 (81.4%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.7.14] (26-33.51-57.96-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), G1>A (240) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV6-21*02 (86.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-DG44 cell line, glycoform alfa
Структура
Иностранные названия
- Tagitanlimabum (латинское)
- Tagitanlimab (английское)
- Tagitanlimab (немецкое)
- Tagitanlimab (французское)
- Tagitanlimab (испанское)
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