Тамгиблимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2411914-36-6

immunoglobulin G4-kappa, anti-[Homo sapiens TIGIT (T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)], Homo sapiens monoclonal antibody;
gamma4 heavy chain Homo sapiens (1-448) [VH (Homo sapiens IGHV1-46*01 (95.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 F1.3>A (236), L1.2>A (237) (233-342), CH3 (343-447), CHS K2>del (448)) (123-448)], (136-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (95.8%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GSKO), glycoform alfa

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