Тамринтамаб памозирин

Rec. INN (наименование, зарегистрированное ВОЗ)

2148334-68-1

immunoglobulin G1-kappa, anti-[Homo sapiens DPEP3 (dipeptidase 3)], humanized monoclonal antibody conjugated to a pyrrolobenzodiazepine dimer (PBD) SC-DR002 via light Cys215;
gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV1-69*01 (85.7%) -(IGHD) -IGHJ6*01 (90.9%)) [8.8.16] (1- 123) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (220) (124-221), hinge C5>S (226) (222-236), CH2 (237-346), CH3 D12 (362), L14 (364) (347-451), CHS K>del (452)) (124-452)], non-covalently associated with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3D-20*01 (86.50%) - IGKJ2*01 (100.0%)) [7.3.9] (1'-108'),-Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (232- 232'':235-235'')-bisdisulfide; conjugated at each CL C126 (215', 215''') to a pyrrolobenzodiazepine dimer (PBD) SCDR002 via a protease-cleavable maleimide linker (LD6.23)

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