Тазлестобарт

Prop. INN (наименование, предложенное ВОЗ)

2850355-80-3

immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-30*01 (94.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v6 CH2 A85.4, A118, A119 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 S85.4>A (299), E118>A (334), K119>A (335), (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-215')-disulfide with L-kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (97.9%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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