Тегопрубарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2628092-47-5

immunoglobulin G1-kappa, anti-[Homo sapiens CD40LG (CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154)], chimeric monoclonal antibody; gamma1 heavy chain chimeric (1-448) [VH Musmus/Homsap (Mus muculus IGHV1S81*02 (84.5%) -(IGHD) -IGHJ3*01 (90.9%) A128>S (118)/Homo sapiens IGHV1-46*01 (76.5%) - (IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v37 h S5, G1v61 h S11, G1v62 h S14, G1v63 CH2 S2 (CH1 K120 (215) (119-216), hinge 1-15 C5>S (221), C11>S (227), C14>S (230) (217-231), CH2 P2>S (239) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], non covalently paired to the kappa light chain chimeric (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-7*01 (87.9%) -IGKJ1*02 (100%)/Homo sapiens IGKV3-11*01 (75.5%) -IGKJ4*01 (90.9%) V124>L (108), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer non covalent, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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