Тегренмеран

Rec. INN (наименование, зарегистрированное ВОЗ)

2889466-36-6

messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein (Omicron sub-lineages B.1.1.529.4 (BA.4) and B.1.1.529.5 (BA.5); based upon GISAID: EPI_ISL_12607996), with a cysteine to serine substitution at residue 233 (corresponding to cys533 in the full- length spike glycoprotein), expressed as a fusion protein with the S glycoprotein signal peptide derived from SARS-CoV-2 Wuhan-Hu 1 strain (GenBank: MN908947.3), flanked by 5' and 3' untranslated regions (UTRs) derived from the human β-globin gene and a 3' polyadenylation (polyA) tail; contains 5-methyluridine instead of uridine (all-U>5-Me-U) and 5-methylcytidine instead of cytidine (all-C>5-Me-C)

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