Телисотузумаб адизутекан

Prop. INN (наименование, предложенное ВОЗ)

2850366-99-1

immunoglobulin G1-kappa, anti-[Homo sapiens MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)], humanized monoclonal antibody, conjugated on an average of 6 cysteinyl residues to adizutecan, comprising a linker and a camptothecin derivative;
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*02 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15 K7>del, T8>C (223), T10>del (217-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (119-445)], (221-218')-disulfide with L-kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV4-1*01 (85.1%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27'-36'.54'-56'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157'), V101 (195') (112'-218')]; dimer (223-223''-225-225'':228-228'')-trisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1SV, expressing the enzyme glutamine synthetase (GS), glycoform alfa; substituted at the sulfur atoms of an average of 6 l-cysteinyl residues among 221, 223, 225, 228, 218', 221'', 223'', 225'', 228'' and 218''' with radical group 2-{[(2S)-1-{[(2S)-1-({3-[(7S)-7-ethyl-7-hydroxy-14-methyl-8,11-dioxo-7,8,11,13-tetrahydro-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]bicyclo[1.1.1]pentan-1-yl}amino)-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-2-oxoethyl (adizutecan)

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