Телпэгфилграстим

Rec. INN (наименование, зарегистрированное ВОЗ)

2325436-66-4

human granulocyte colony-stimulating factor (G-CSF, pluripoietin) short isoform, variant (A¹>M), produced in Escherichia coli, pegylated with one N-{[α-methylpoly(oxyethylene)-ω-oxy]acetyl}-N-[α-methylpoly(oxyethylene)-ω-yl]glycyl group at N² of M¹ (85-95%) or at N⁶ of K¹⁷ (3-13%) or at N⁶ of K²⁴, K³⁵ and K⁴¹ (total not more than 5 %);
[1-L-methionine]human granulocyte colony-stimulating factor (GCSF, pluripoietin) short isoform, produced in Escherichia coli, substituted with one N-{[α-methylpoly(oxyeth-ylene)-ω-oxy]acetyl}-N-[α-methylpoly(oxyethylene)-ω-yl]glycyl group at N² of Met¹ (85-95 %) or at N⁶ of Lys¹⁷ (3-13 %) or one other lysine residue (total not more than 5 %)

C₈₅₃H₁₃₅₂N₂₂₄O₂₄₇S₉[(C₂H₄O)_2n] (n ≈ 400-500)

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