Теподитамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2044679-53-8

immunoglobulin G1-kappa, anti-[Homo sapiens CLEC12A (C-type lectin domain family 12 member A, dendritic cell-associated lectin 2, DCAL-2, myeloid inhibitory C-type lectin-like receptor, MICL, CD371) and anti-[Homo sapiens CD3 epsilon (CD3E, Leu-4)], human monoclonal antibody, bispecific;
gamma1 heavy chain anti-CLEC12A (1-447) [Homo sapiens VH (IGHV1-46*01 (99.0%) -(IGHD) -IGHJ4*01 (93.3%)) [8.8.11] (1-118) -Homo sapiens IGHG1*03, G1m3 nG1m1 (CH1 R120 (215) (119-216), hinge (217-231), CH2 [L1.2>G (236), G1.1>R (237)] (232-341), CH3 E12 (357), M14 (359) [L7>D (352), L24>E (369)] (342-446), CHS K2>del (447)) (119-447)]; (221-214')-disulfide with kappa light chain (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (100.00%) -IGKJ1*01 (100%)) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')];
gamma1 heavy chain anti-CD3E (1''-447'') [Homo sapiens VH (IGHV3-33*01 (89.8%) -(IGHD) -IGHJ5*02 (100%)) [8.8.11] (1''-118'') -Homo sapiens IGHG1*03, G1m3 nG1m1 (CH1 R120 (215) (119-216), hinge (217-231), CH2 [L1.2>G (236), G1.1>R (237)] (232-341), CH3 [L7>K (352), T22>K (367)] (342-446), CHS K>del (447)) (119''-447'')], (221''-214''')-disulfide with kappa light chain (1'''-214''') [Homo sapiens V-KAPPA (IGKV1-39*01 (100%) -IGKJ1*01 (100%)) [6.3.9] (1'''-107''') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'''-214''')]; dimer (227-227'':230-230'')-bisdisulfide

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