Теропавимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2417213-72-8

immunoglobulin G1-kappa, anti-[human immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein (HIV-1 gp120) CD4 binding site (CD4bs)], monoclonal antibody;
gamma1 heavy chain (1-452) [VH (Homo sapiens IGHV1-2*02, insert D84.1, F84.2, D85.2, T85.1 (77-80), (62.7%) -(IGHD) -IGHJ3*01 (85.7%) Q120>S (115), M123>Q (118), CDR-IMGT [8.8.12] (26-33.51-58.101-112)) (1-123) -Homo sapiens IGHG1*01 G1m17,1, G1v24 CH3 L107, S114 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 (237-346), CH3 D12 (362), L14 (364), M107>L (434), N114>S (440) (347-451), CHS K2>del (452)) (124-452)], (226-206')-disulfide with kappa light chain (1'-206') [V-KAPPA (Homo sapiens IGKV1-33*01 (72.8%) -IGKJ5*01 (71.4%) E119>D (97), I120>L (98), CDR-IMGT [3.3.13] (26-28.46-48.85-97)) (1'-99') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (145), V101 (183) (100'-206')]; dimer (232-232'':235-235'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1SV cell line, glycoform alfa

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