Тесриветцел

Rec. INN (наименование, зарегистрированное ВОЗ)

485665260

equine allogeneic tenogenic-primed mesenchymal stromal/stem cells (MSCs), isolated from peripheral blood mononuclear cells (PBMCs) collected from donor horses. The MSCs are selected for by growing the PBMCs in media containing fetal bovine serum (FBS) and dexamethasone. The cells are then expanded in media containing FBS, and prior to differentiation towards tenocytes by growth in media containing FBS, fibroblast-growth factor 2 (FGF-2) and insulin-like growth factor-1 (IGF-I)., The final cells are characterized by their stretched spindle shaped morphology, and by expression of the cellular surface markers CD90 (≥95%) and CD40 (≥85%) and absence of MHC class II expression (≤2%). The cells secrete prostaglandin E2 (PGE2) and express the actin alpha 2 (ACTA2) gene (>2.3 fold)

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