Тибулизумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB14848

1849636-24-3

immunoglobulin G4-kappa anti-[Homo sapiens TNFSF13B (tumor necrosis factor (TNF) superfamily member 13B, BAFF, THANK, TALL1, TALL-1, BLYS, BLyS, B cell activating factor, B lymphocyte activator, CD257)] , each heavy chain being fused to a scFv anti-[Homo sapiens IL17A (interleukin 17A, IL-17A)], humanized monoclonal antibody, bispecific tetravalent;
gamma4 heavy chain anti-TNFSF13B fused to a scFv anti-IL17A (1-714) [gamma4 heavy chain {(Homo sapiens VH (IGHV4-34*01 (100.00%) -(IGHD) -IGHJ4*01) [8.7.17] (1-123) -Homo sapiens IGHG4*01 (CH1 (124-221), hinge S10>P (231) (222-233), CH2 (234-343), CH3 L125>del (344-447), CHS G1>del, K2>del) (124-447)} (1-447) -16-mer linker (448-463) -scFv {(humanized VH (Homo sapiens IGHV1-69*01 (83.70%) -(IGHD) -IGHJ4*01) [8.8.12] (464-582) -20-mer tetra(tetraglycyl-seryl) linker (583-602) -humanized V-KAPPA (Homo sapiens IGKV2D-29*02 (89.00%) -IGKJ2*02) [11.3.9] (603-714)} (464-714)], (137-214')-disulfide with kappa light chain anti-TNFSF13B (1'-214') [Homo sapiens V-KAPPA (IGKV3-11*01 (97.90%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*05, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide

Поделиться этой страницей