Икатолимаб
TifcemalimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2236068-83-8
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens BTLA (B and T lymphocyte associated, BTLA1, CD272)], chimeric monoclonal antibody;
gamma4 heavy chain chimeric (1-446) [VH (Mus musculus IGHV14-3*02 (82.3%) -IGHJ3*01 (91.7%)/Homo sapiens IGHV1-3*01 (77.1%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (120-446)], (133-219')-disulfide with kappa light chain chimeric (1'-219') [V-KAPPA (Mus musculus IGKV1-135*01 (92%) -IGKJ2*03 (91.7%)/Homo sapiens IGKV2-30*01 (87.0%) -IGKJ2*01 (100%)) CDR-IMGT [11.3.9] (27-47.55-57.94-102) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (158), V101 (196) (113'-219')];
dimer (225-225'':228-228'')-bisdisulfide; produced in Chinese hamster ovary (CHO) cells, glycoform alfa.
gamma4 heavy chain chimeric (1-446) [VH (Mus musculus IGHV14-3*02 (82.3%) -IGHJ3*01 (91.7%)/Homo sapiens IGHV1-3*01 (77.1%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (120-446)], (133-219')-disulfide with kappa light chain chimeric (1'-219') [V-KAPPA (Mus musculus IGKV1-135*01 (92%) -IGKJ2*03 (91.7%)/Homo sapiens IGKV2-30*01 (87.0%) -IGKJ2*01 (100%)) CDR-IMGT [11.3.9] (27-47.55-57.94-102) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (158), V101 (196) (113'-219')];
dimer (225-225'':228-228'')-bisdisulfide; produced in Chinese hamster ovary (CHO) cells, glycoform alfa.
Структура
Иностранные названия
- Tifcemalimabum (латинское)
- Tifcemalimab (английское)
- Tifcemalimab (немецкое)
- Tifcémalimab (французское)
- Tifcemalimab (испанское)
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