Тимдарпацепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2749520-17-8

human signal-regulatory protein alpha (SIRPα, tyrosine-protein phosphatase non-receptor type substrate 1) receptor domain 1 fragment (1-133) natural variant V2 (SIRPα V2; L¹⁴>S, T²⁰>S, T²²>I, R²⁴>H, A²⁷>V, G⁴⁵>A, D⁶⁵>E, L66>S, N⁷⁰>E, R⁷⁷>S, G⁷⁹>S, D¹⁰⁰>del, V¹⁰²>T¹⁰¹) engineered variant (N⁸⁰>A), fused to a human immunoglobulin G1 C-terminal Fc fragment (134-365) [Homo sapiens IGHG1*01; hinge: 134-148; CH2: 149-258; CH3: 259-363; CHS: 364-365]), disulfide bridged dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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