Тивиденофусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

DB17628

2641020-57-5

human iduronate 2-sulfatase (IDS, α-L-iduronate sulfate sulfatase, EC:3.1.6.13) pro-protein (1-525), fused via the peptide linker ⁵²⁶GGGGS⁵³⁰ to a human immunoglobulin G1 C-terminal Fc fragment (531-757) variant (L⁵⁴⁴>A, L⁵⁴⁵>A, T⁶⁷⁶>S, L⁶⁷⁸>A, Y⁷¹⁷>V), disulfide bridged to an engineered human immunoglobulin G1 anti-(human type 1 transferrin receptor (TfR1)) C-terminal Fc fragment (1'-227'), variant (L^14'>A, L1^5'>A, T^146'>W, N^164'>Y, Q^166'>T, P^167'>E, E^168'>W, N^169'>A, D^193'>T, S^195'>E, R^196'>E, N^201'>F), heterodimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; human iduronate 2-sulfatase (IDS, α-L-iduronate sulfate sulfatase, idursulfase, EC:3.1.6.13, UniProt:P22304), pro-protein (1-525), fused via the peptidic linker G₄S (526-530) with a human immunoglobulin G1 hinge-CH2-CH3 Fc fragment [Homo sapiens IGHG1*01 (531-757) (hinge (531-540, N-terminal hinge residues EPKSC deleted), CH2 L⁵⁴⁴>A, L⁵⁴⁵>A (541-650), CH3 T⁶⁷⁶>S, L⁶⁷⁸>A, Y⁷¹⁷>V (651-755), CHS (756-757))], (536-6':539-9')-bisdisulfide with a human immunoglobulin G1 hinge- CH2-CH3 Fc fragment [Homo sapiens IGHG1*01 (1'- 227') (hinge (1-10), CH2 L^14'>A, L^15'>A (11-120), CH3 T^146'>W, N^164'>Y, Q^166'>T, P^167'>E, E^168'>W, N^169'>A, D^193'>T, S^195'>E, R^196'>E, N^201'>F engineered for binding to the human type 1 transferrin receptor (TfR1) (121- 225), CHS (226-227))], produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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