Тиксагевимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16394

2420564-02-7

immunoglobulin G1-kappa, anti-[Homo sapiens severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV1-58*01 (98.0%) -(IGHD) -IGHJ3*02 (93.8%)) CDR-IMGT [8.8.16] (26-33.51-58.97-112) (1-123) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v21 CH2 Y15.1, T16, E18, G1v39 CH2 F1.3, E1.2, S116 (CH1 R120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>F (240), L1.2>E (241), M15.1>Y (258), S16>T (260), T18>E (262), P116>S (337) (237-346), CH3 E12 (362), M14 (364) (347-451), CHS (452-453)) (124-453)], (226-216')-disulfide with kappa light chain Homo sapiens (1'-216') [V-KAPPA (Homo sapiens IGKV3-20*01 (98.9%) -IGKJ1*01 (100%)) CDR-IMGT [7.3.10] (27-33.51-53.90-99) (1'-109') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (155), V101 (193) (110'-216')]; dimer (232-232":235-235")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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