Тобемстомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2648839-43-2

immunoglobulin G1-kappa with crossed domains, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)] and anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody, bispecific;
gamma1 heavy chain with crossed V-kappa anti-PDCD1 (1-443) [V-KAPPA humanized (Homo sapiens IGKV4-1*01 (82.2%) -IGKJ1*01 (100%), CDR-IMGT) [10.3.9] (27-36.54-56.93-101) (1-111) -2-mer biseryl linker (112-113) -Homo sapiens IGHG1*01, G1m17,1, G1v14-49 CH2 A1.3, A1.2, G114, G1v32 CH3 W22 (knob) (CH1 K120 (210) (114-211), hinge 1-15 (212-226), CH2 L1.3>A (230), L1.2>A (231), P114>G (325) (227- 336), CH3 D12 (352), L14 (354), S10>C (350), T22>W (362) (337- 441), CHS (442-443)) (112-443)], (216-227')-disulfide with kappa light chain with crossed VH anti-PDCD1 (1'-227') [VH humanized (Homo sapiens IGHV3-23*01 (90.6%) -(IGHD) -IGHJ5*01 (92.9%)), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1'-120') -Homo sapiens IGKC*01 (99.1%), R1.4>A (121), T1.3>S (122), Km3 A45.1 (166), V101 (204) (121'-227')]; gamma1 heavy chain anti-LAG3 (1''-451'') [VH humanized (Homo sapiens IGHV3-23*01 (86.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1''-121'') -Homo sapiens IGHG1*01, G1m17,1, G1v14-49 CH2 A1.3, A1.2, G114, G1v33 CH3 S22, A24, V86 (hole) (CH1 K26>E (151), K119>E (217), K120 (218) (122''-219''), hinge 1-15 (220''-234''), CH2 L1.3>A (238), L1.2>A (239), P114>G (333) (235''-344''), CH3 D12 (360), L14 (362), Y5>C (353), T22>S (370), L24>A (372), Y86>V (411) (345''-449''), CHS (450''-451'')) (122''-451'')], (224''-214''')-disulfide with kappa light chain anti-LAG3 (1'''-214''') [Homo sapiens V-KAPPA (IGKV1D-39*01 (96.8%) -IGKJ4*01 (100%)) [6.3.9], CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'''-107''') -Homo sapiens IGKC*01 (98.1%), E12>R (123), Q13>K (124) (108'''-214''')]; dimer (222-230":225-233":350-353")-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa

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