Томлигисиран

Rec. INN (наименование, зарегистрированное ВОЗ)

all-P-ambo-O-[(2R,3S)-2-(hydroxymethyl)oxolan-3-yl] hydrogen 5'-O-({[(2R,3S)-3-{[({cis-4-[(3S,8S)-17-{[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy}-3,8-bis{[2-(2-{[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy}ethoxy)ethyl]carbamoyl}-6,11-dioxo-15-oxa2,7,12-triazaheptadecan-1-oyl]cyclohexyl}oxy)hydroxyphosphorothioyl]oxy}-oxolan-2- yl]methoxy}hydroxyphosphorothioyl)-2'-O-methylcytidylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-deoxy2'-fluorocytidylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyl-P-thio-3'-adenylate, duplex with all-P-ambo-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-deoxy-2'-fluoro-P-thioadenylyl-(3'→5')-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'- fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'- fluoroguanylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'- fluoroadenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methylguanosine

C₄₉₂H₆₅₁F₁₂N₁₆₄O₃₁₀P₄₃S₇

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