Тозоракимаб
TozorakimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2376858-66-9
Химическое название
immunoglobulin G1-lambda2, anti-[Homo sapiens IL33 (interleukin 33, DVS27, NF-HEV, IL1F11)], monoclonal antibody;
gamma1 heavy chain (1-456) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (85.7%) L123>M (121)) CDR-IMGT [8.8.19] (26-33.51-58.97-115) (1-126) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (223) (127-224), hinge 1-15 (225-239), CH2 (240-349), CH3 E12 (365), M14 (367) (350-454), CHS (455-456)) (127-456)], (229-211')-disulfide with lambda2 light chain (1'-212') [V-LAMBDA (Homo sapiens IGLV3-1*01 (86.2%) -IGLJ2*01 (100%)) CDR-IMGT [6.3.9] (26-31.49-51.88-96) (1'-106') -Homo sapiens IGLC2*01 (100%) (107'-212')]; dimer (235-235'':238-238'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
gamma1 heavy chain (1-456) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (85.7%) L123>M (121)) CDR-IMGT [8.8.19] (26-33.51-58.97-115) (1-126) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (223) (127-224), hinge 1-15 (225-239), CH2 (240-349), CH3 E12 (365), M14 (367) (350-454), CHS (455-456)) (127-456)], (229-211')-disulfide with lambda2 light chain (1'-212') [V-LAMBDA (Homo sapiens IGLV3-1*01 (86.2%) -IGLJ2*01 (100%)) CDR-IMGT [6.3.9] (26-31.49-51.88-96) (1'-106') -Homo sapiens IGLC2*01 (100%) (107'-212')]; dimer (235-235'':238-238'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
Структура
Иностранные названия
- Tozorakimabum (латинское)
- Tozorakimab (английское)
- Tozorakimab (немецкое)
- Tozorakimab (французское)
- Tozorakimab (испанское)
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