Трастузумаб кориксетан
Trastuzumab corixetanМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2454636-31-6
Химическое название
immunoglobulin G1-kappa, anti-[<em>Homo sapiens </em>ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated to <em>corixetan</em>, comprising a linker and an octadentate chelator;</p>
<p>gamma1 heavy chain humanized (1-449) [VH (<em>Homo sapiens</em> IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -<em>Homo sapiens</em> IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K2>del (449)) (121-449)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (<em>Homo sapiens</em> IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -<em>Homo sapiens</em> IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229":232-232")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa, conjugated to the chelator group <em>corixetan</em> on an average of 0.5 lysyl per antibody
<p>gamma1 heavy chain humanized (1-449) [VH (<em>Homo sapiens</em> IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -<em>Homo sapiens</em> IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K2>del (449)) (121-449)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (<em>Homo sapiens</em> IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -<em>Homo sapiens</em> IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229":232-232")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa, conjugated to the chelator group <em>corixetan</em> on an average of 0.5 lysyl per antibody
Структура
Иностранные названия
- Trastuzumabum corixetanum (латинское)
- Trastuzumab corixetan (английское)
- Trastuzumab corixetan (немецкое)
- Trastuzumab corixétan (французское)
- Trastuzumab corixetán (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Трастузумаб кориксетан: