Тревотамиг

Prop. INN (наименование, предложенное ВОЗ)

2920215-79-6

immunoglobulin H-gamma1_L-kappa-scFvhl dimer bisdisulfide, anti-[Homo sapiens EPCAM (epithelial cell adhesion molecule, tumor-associated calcium signal transducer 1, TACSTD1, gastrointestinal tumor-associated protein 2, GA733-2, epithelial glycoprotein 2, EGP-2, KSA, KS1/4 antigen, M4S1, tumor antigen 17-1A, Ep-CAM, EpCAM, CD326)] and scFv anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized and chimeric monoclonal antibody, bispecific, tetravalent;
H-gamma1 heavy chain anti-EPCAM humanized (1-447) [VH (Homo sapiens IGHV3-15*07 (74.5%) -(IGHD) -IGHJ1*01 (85.7%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01 G1m17,1 CH1 K120, CH3 D12, L14, G1v36 CH2 Q84.4 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 N84.4>Q (298) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS K2>del (447)) (119-447)]; (221-212')-disulfide with L-kappa light chain anti-EPCAM humanized fused to a scFv anti-CD3E chimeric (1'-419') [L-KAPPA anti-EPCAM humanized (1'-212') [V-KAPPA (Homo sapiens IGKV1-39*01 (82.2%) -IGKJ1*01 (100%), CDR-IMGT [5.3.8] (27'-31'.49'-51'.88'-95')) (1'-105') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (151'), V101 (189')) (106'-212')] -7-mer (seryl-arginyl-seryl-tetraglycyl) linker (213'-219') -scFvhl anti-CD3E chimeric (220'-419') [VH Musmus/Homsap (Mus musculus IGHV10-1*04 (92.0%) -IGHD -IGHJ3*01 (92.3%) A128>S (344')/Homo sapiens IGHV3-72*01 (85.0%) -IGKJ6*01 (90.9%) T123>L (339'), CDR-IMGT [8.10.16] (245'-252'.270'-279'.318'-333')) (220'-344') -14-mer tetrakis(diglycyl-seryl)-diglycyl linker (345'-358') -V-LAMBDA Musmus/Homsap (Mus musculus IGLV1*01 (79.2%) -IGLJ1*01 (100%)/Homo sapiens IGLV7-46*01 (76.8%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (384'-392'.410'-412'.449'-457')) (359'-469')]]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, non-glycosylated

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