Тросунилимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2550297-60-2

immunoglobulin G1-kappa, anti-[Homo sapiens integrin ITGA4_ITGB7 (integrin alpha4 (CD49d)_beta7, integrin α4β7, lymphocyte Peyer's patch adhesion molecule 1, LPAM-1)];
gamma1 heavy chain (1-442) [VH (Homo sapiens IGHV1-69*11 (80.0%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (107), CDR-IMGT [8.8.5] (26-33.51-58.97-101)) (1-112) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (209) (113-210), hinge 1-15 (211-225), CH2 (226-335), CH3 E12 (351), M14 (353) (336-440), CHS (441-442)) (113-442)], (215-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV14-100*01 (85.3%) -IGKJ1*01 (91.7%) L124>V (104)/Homo sapiens IGKV1-33*01 (80.0%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (221-221'':224-224'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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