Тулисокибарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2648504-55-4

immunoglobulin G1-kappa, anti-[Homo sapiens TNFSF15 (tumor necrosis factor (TNF) superfamily member 15, TL1A, vascular endothelial cell growth inhibitor 192-A, VEGI192A), membrane and soluble], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*02 (80.6%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2, G1v4 CH2 A114 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 L1.3>A (233), L1.2>A (234), P114>A (328) (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-213')-disulfide with kappa light chain humanized (1'-213') [V-KAPPA (Homo sapiens IGKV3D-11*02 (85.6%) -IGKJ4*01 (90.9%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (225-225'': 228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

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