Тусамитамаб
TusamitamabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2349294-95-5
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5, CEA, CD66e)], monoclonal antibody;
gamma1 heavy chain (1-449) [VH (Mus musculus IGHV5-12-1*01 (86.6%) -(IGHD) -IGHJ3*01 (92.9%)/Homo sapiens IGHV3-23*01 (77.3%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS K>del (449) (121-449)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV12-44*01 (87.4%) -IGKJ4*01 (100%)/Homo sapiens IGKV1-39*01 (82.1%) -IGKJ2*02 (90.9%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-derived cell line, glycoform alfa
gamma1 heavy chain (1-449) [VH (Mus musculus IGHV5-12-1*01 (86.6%) -(IGHD) -IGHJ3*01 (92.9%)/Homo sapiens IGHV3-23*01 (77.3%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS K>del (449) (121-449)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV12-44*01 (87.4%) -IGKJ4*01 (100%)/Homo sapiens IGKV1-39*01 (82.1%) -IGKJ2*02 (90.9%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-derived cell line, glycoform alfa
Структура
Иностранные названия
- Tusamitamabum (латинское)
- Tusamitamab (английское)
- Tusamitamab (немецкое)
- Tusamitamab (французское)
- Tusamitamab (испанское)
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