Тувонралимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2417649-44-4

immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-33*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03v G1m3>G1m17, nG1m1 (CH1 K26>D (148), F81>C (171), V84>C (174), R120>K (215) (119-216), hinge 1-15 C5>G (221) (217-231), CH2 R17>K (256) (232-341), CH3 E12 (357), M14 (359), D84.2>R (400), K88>E (410) (342-446), CHS (447-448)) (119-448)], (171-162':174-160')-bisdisulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (92.7%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (97.2%), Km3 S20>K (131), A45.1 (153), Q79>C (160), S81>C (162), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-S cell line, glycoform alfa

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