Убаматамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2305629-50-7

immunoglobulin G4-kappa, anti-[Homo sapiens MUC16 (mucin 16, MUC-16, cancer antigen 125, CA125)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], monoclonal antibody, bispecific;
gamma4 heavy chain anti-MUC16 (1-443) [VH anti-MUC16 (Homo sapiens IGHV3-11*01 (88.8%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (118-215), hinge 1-12 S10>P (225) (215-227), CH2 E1.4,F1.3>P1.3 (230), L1.2>V (231), G1.1>A (232) (228-336), CH3 (337-441), CHS (442-443)) (118-443)], (131-215')-disulfide with kappa light chain (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (97.9%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')];
gamma4 heavy chain anti-CD3E (1''-450'') [VH anti-CD3E (Homo sapiens IGHV3-9*01 (98.0%) -(IGHD) -IGHJ1*01 (90.9%) L123>T (119), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1''-124'') -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (125''-222''), hinge 1-12 S10>P (232) (223''-234''), CH2 E1.4,F1.3>P1.3 (237), L1.2>V (238), G1.1>A (239) (235''-343''), CH3 H115>R (438), Y116>F (439), L125>P (448) (344''-448''), CHS (449''-450'')) (125''-450'')], (138''-215''')-disulfide with kappa light chain (1'''-215''') [V-KAPPA (Homo sapiens IGKV1-39*01 (97.8%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'''-108''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'''-215''')]; dimer (224-230'':227-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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