Ублетамиг

Prop. INN (наименование, предложенное ВОЗ)

immunoglobulin (H-gamma4_L-kappa)_( H-gamma4_L-kappa), anti-[Homo sapiens MUC16 (mucin 16, MUC-16, cancer antigen 125, CA125)] and anti-[Homo sapiens CD28 (T cell specific surface glycoprotein CD28, TP44)], Homo sapiens monoclonal antibody, bispecific, bivalent;
H-gamma4 heavy chain anti-MUC16 Homo sapiens (1-455) [VH (Homo sapiens IGHV3-49*04 (93.9%) -(IGHD) -IGHJ6*04 (90.0%) K120>R (121), CDR-IMGT [8.10.20] (26-33.51-60.99-118)) (1-129) -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, 12-G4v5 h P10, 6-G4v7 CH2 delE1.4, P1.3, V1.2, A1.1 (CH1 (130-227), hinge 1-12 S10>P (237) (228-239), CH2 E1.4>del, F1.3>P (242), L1.2>V (243), G1.1>A (244), L92 (318) (240-348), CH3 (349-453), CHS (454-455)) (130-455)], (143-215')-disulfide with common L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (154'), V101 (192') (109'-215')];
H-gamma4 heavy chain anti-CD28 Homo sapiens (1''-448'') [VH (Homo sapiens IGHV4-59*01 (96.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.7.16] (26''-33''.51''-57''.96''-111'')) (1''-122'') -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, 12-G4v5 h P10, 6-G4v7 CH2 delE1.4, P1.3, V1.2, A1.1, 10-G4v8 CH3 R115, F116, P125 (CH1 (123''-220''), hinge 1-12 S10>P (230'') (221''-232''), CH2 E1.4>del, F1.3>P (235''), L1.2>V (236''), G1.1>A (237''), L92 (311'') (233''-341''), CH3 H115>R (436''), Y116>F (437''), L125>P (446'') (342''-446''), CHS (447''-448'')) (123''-448'')], (136''-215''')-disulfide with common L-kappa light chain Homo sapiens (1'''-215''') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'''-33'''.51'''-53'''.90'''-98''')) (1'''-108''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (154'''), V101 (192''') (109'''-215''')]; dimer (235-228'': 238-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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