Упановимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2500633-46-3

immunoglobulin G1-kappa, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein, receptor binding domain (RBD)], monoclonal antibody;
gamma1 heavy chain (1-451) [VH Musmus/Homsap (Mus musculus IGHV5-9-4*01 (89.8%) -(IGHD) -IGHJ3*01 (91.7%) A128>S (121)/Homo sapiens IGHV3-21*01 (85.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-2*01 (82.8%) -IGKJ2*03 (81.8%) S120>Q (104), L124>V (108)/Homo sapiens IGKV3D-11*02 (80.9%) -IGKJ1*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (230-230'':233-233'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-DG44 cell line, glycoform alfa

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