Упинитатуг рилсодотин

Rec. INN (наименование, зарегистрированное ВОЗ)

immunoglobulin G1-kappa, anti-[Homo sapiens SLC34A2 (solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B)], monoclonal antibody, conjugated, via a thioether bond, to 3 to 5 flexible polymers PHF-BA-EG2-MI-AF-HPA-Ala, each comprising maleimide (MI) bioconjugation linkers and 3 to 4 auristatin F- hydroxypropylamide-l-alanine (AF-HPA-Ala), with a drug ratio of 12:1 to 15:1;
gamma1 heavy chain (1-449) [VH (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) -glycinyl (120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K>del (449)) (121-449)], (223-215')-disulfide with kappa light chain (1’-215’) [V-KAPPA (Mus musculus IGKV10-94*01 (84.2%) -IGKJ5*01 (91.7%)/Homo sapiens IGKV1-33*01 (83.2%) -IGKJ2*01 (90.9%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -arginyl (108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109''-215')];
dimer (229-229":232-232")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; conjugated, via a thioether bond, from 3 to 5 flexible biodegradable polymers, poly(l-hydroxymethylethylene hydroxymethyl-formal) (PHF)-BA-EG2-MI-AF-HPA-Ala, each comprising maleimide (MI) conjugation linkers and 3 to 4 cytotoxic auristatin F- hydroxypropylamide-l-alanine (AF-HPA-Ala), with a drug ratio of 12:1 to 15:1;

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