Упревстобарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2762201-85-2

immunoglobulin G1-kappa, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5' nucleotidase, 5’-NT, NT5, CD73)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV5-51*01 (86.7%) -(IGHD) -IGHJ4*01 (85.7%) Q120>A (113), L123>T (116), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120 CH3 E12, M14, G1v29 CH2 A84.4 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 N84.4>A (301) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS K2>del (450)) (122-450)], (224-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV4-1*01 (83.2%) -IGKJ2*01 (91.7%) Q120>G (100'), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide , produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 lacking the glutamine synthetase (GS-KO) gene, non-glycosylated

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