Велапрумиг

Prop. INN (наименование, предложенное ВОЗ)

2988741-17-7

immunoglobulin scFvkh-L-VH-G1(CH1-h)_scFvkh-L-kappa, anti-[Homo sapiens CD40LG (CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154)] and anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)], monoclonal antibody, bispecific, trivalent;
fused scFvkh-L-VH-G1(CH1-h) chain anti-CD40LG and anti-ALB (1-483) [scFvkh anti-CD40LG (1-245) [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-7*01 (87.9%) -IGKJ1*02 (100%)/Homo sapiens IGKV3-11*01 (75.5%) -IGKJ4*01 (90.9%) V124>L (108), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1-112) -15-mer tris(tetraglycyl-seryl) linker (113-127) -VH Musmus/Homsap (Mus musculus IGHV1-47-14*01 (88.8%) -(IGHD) -IGHJ3*01 (90.9%) A128>S (245)/Homo sapiens IGHV1-46*01 (76.5%) -IGHD -IGHJ1*01 (100%), CDR-IMGT [8.8.11] (153-160.178-185.224-234)) (128-245)] -15-mer tris(tetraglycyl-seryl) linker (246-260) -VH-G1(CH1-h) anti-ALB (261-483) [VH anti-ALB (Homo sapiens IGHV3-21*01 (90.8%) -IGHD -IGHJ4*01 (92.9%), CDR-IMGT [8.8.13] (286-293.311-318.357-369)) (261-380) -Homo sapiens IGHG1*01 CH1-h, G1m17,1 CH1 K120, 10-G1v100-1 CH1 E16, 15-G1v37 h S5 (CH1 G16>E (400), K120 (477) (381-478), hinge 1-5 C5>S (483) (479-483)) (381-483)]];
fused scFvkh-L-KAPPA chain anti-CD40LG and anti-ALB (1'-478') [scFvkh anti-CD40LG (1'-245') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-7*01 (87.9%) -IGKJ1*02 (100%)/Homo sapiens IGKV3-11*01 (75.5%) -IGKJ4*01 (90.9%) V124>L (108'), CDR-IMGT [10.3.9] (27'-36'.54'-56'.93'-101')) (1'-112') -15-mer tris(tetraglycyl-seryl) linker (113'-127') -VH Musmus/Homsap (Mus musculus IGHV1-47-14*01 (88.8%) -(IGHD) -IGHJ3*01 (90.9%) A128>S (245')/Homo sapiens IGHV1-46*01 (76.5%) -IGHD -IGHJ1*01 (100%), CDR-IMGT [8.8.11] (153'-160'.178'-185'.224'-234')) (128'-245')] -18-mer (GSTSGSGKPGSGEGSTKG) linker (246'-263') -L-KAPPA anti-ALB (264'-478') [V-KAPPA anti-ALB (Homo sapiens IGKV3-15*01 (85.7%) -IGKJ2*01 (90.9%) K123>Q (367'), CDR-IMGT [6.3.10] (290'-295'.313'-315'.352'-361')) (264'-371') -Homo sapiens IGKC*01, Km3 A45.1, V101, 15-KCv36 S126 (C-KAPPA A45.1 (417'), V101 (455'), C226>S (478') (372'-478')]], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, non-glycosylated

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