Велинотамиг

Prop. INN (наименование, предложенное ВОЗ)

2848586-49-0

immunoglobulin H-gamma1_L-kappa/H-gamma1_L-kappa, anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)] and anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF) receptor superfamily member 17, B cell maturation antigen, BCMA, TNFRSF13A, CD269)], Homo sapiens monoclonal antibody, bispecific;
H-gamma1 heavy chain anti-CD3E Homo sapiens (1-445) [VH (Homo sapiens IGHV3-33*01 (94.9%) -(IGHD) -IGHJ2*01 (88.2%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03 G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v39 CH2 F1.3, E1.2, S116, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 R120 (215) (119-216), hinge 1-12 P2>R (218), DKTHT 6-10 > VE (222, 223) (217-228), CH2 L1.3>F (232), L1.2>E (233), P116>S (329) (229-338), CH3 S10>C (352), E12 (354), M14 (356), T22>W (364) (339-443), CHS (444-445)) (119-445)], (221-214')-disulfide with common L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (90.5%)  -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
H-gamma1 heavy chain anti-TNFRSF17 Homo sapiens (1''-448'') [VH (Homo sapiens IGHV1-3*01 (81.6%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (116''), CDR-IMGT [8.8.14] (26''-33''.51''-58''.97''-110'')) (1''-121'') -Homo sapiens IGHG1*03 noG1m3, nG1m1 CH1 T120, CH3 E12, M14, G1v39 CH2 F1.3, E1.2, S116, G1v75  CH3 C5, G1v33 CH3 S22, A24, V86 (hole) (CH1 G16>E (141''), N107>D (207''), R120>T (218'') (122''-219''), hinge 1-12 P2>R (221''), DKTHT 6-10 > VE (225'', 226'') (220''-231''), CH2 L1.3>F (235''), L1.2>E (236''), H30>Q (269''), K38>Q (275''), P116>S (332'') (232''-341''), CH3 Y5>C (350''), R11>Q (356''), E12 (357''), M14 (359''), T22>S (367''), L24>A (369''), Y86>V (408''), Q98>E (420'') (342''-446''), CHS (447''-448'')) (122''-448'')], (224''-214''')-disulfide with common L-kappa light chain Homo sapiens (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-39*01 (90.5%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'''), V101 (191''')) (108'''-214''')]; dimer (224-227'':227-230'':352-350'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Поделиться этой страницей