Велуковакап

Rec. INN (наименование, зарегистрированное ВОЗ)

2856375-51-2

N-L-glycyl-split protein tag peptide (2-15) fused via the peptide linker ¹⁶GSGTAGGGSGS²⁶ to Acinetobacter phage AP205 coat protein fragment (Met1>del, 2-131, 27-156 in the current sequence), produced in Escherichia coli, conjugated via isopeptide bond (formed by the reaction between N⁹ and K³² with associated loss of one amino group) to N-L-glycyl-catcher peptide fragment (2-114) derived from Streptococcus dysgalactiae fibronectin binding protein fused via peptide linker ¹¹⁵GSGS¹¹⁸ to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (S glycoprotein) receptor binding domain (RBD) fragment (GenBank ID: QIA20044.1; 306-578, 119-391 in the current sequence) fused via peptide linker ³⁹²GSGS³⁹⁵ to a ³⁹⁶EPEA³⁹⁹ C-terminal tag peptide, produced in Drosophila melanogaster S2 cells, glycoform alfa. The Acinetobacter phage AP205 coat protein-containing monomers self-assemble into a virus-like particle (VLP) consisting of 180 subunits of which approximately 61 surface exposed copies spontaneously conjugate with the RBD-containing recombinant fusion protein when mixed together

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