Венсобафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

DB17716

2724922-85-2

umanized immunoglobulin G4-kappa, anti-(human complement factor C5) engineered heavy chain variant (S²³³>P, M⁴³³>L, N⁴³⁹>A), fused at the C-terminus of the heavy chain (1-452) to a human complement factor H (CFH, H factor 1, HF1) functional domain fragment (1-306, 453-758 in the current sequence), variant (V44>I496), disulfide bridged dimer , produced in Chinese hamster ovary (CHO) cells, glycoform alfa; humanized monoclonal antibody fusion with human complement factor H; type: IgG4-kappa; antigen: human complement C5, CPAMD4 (C5); CDR source: Mus musculus (humanized by CDR grafting); heavy chain class: gamma 4; HV germline: Homo sapiens IGHV1-18*01; HJ germline: Homo sapiens IGHJ3*01; HC germline: Homo sapiens IGHG4*01; VH: 1-125; CH1: 126-223; hinge: 224-235 (S233P hinge stabilization); CH2: 236-345; CH3: 346-450 (M433L, N439A; enhance FcRn binding); CHS: 451-452; LV germline: Homo sapiens IGKV1-9*01; LJ germline: Homo sapiens IGKJ2*01; LC germline: Homo sapiens IGKC*01; VL: 1-107; CL: 108-214; CDR Kabat H1: DYHFD (31-35); CDR Kabat H2: DISMNYGYHIYNQKFKD (50-66); CDR Kabat H3: RDIRYSGNSYKWYFDE (99-114); CDR Kabat L1: RTSKSISKHLA (24-34); CDR Kabat L2: SGSTLQS (50-56); CDR Kabat L3: QQHNEYPYT (89-97); fusion protein heavy: 453-758; human complement factor H residues 1-306 (CFH)

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