Вепситамаб

Vepsitamab

МНН

Rec. INN (зарегистрированное ВОЗ)

CAS

2413453-53-7

Химическое название

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens MUC17 (mucin 17, cell surface associated)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], monoclonal antibody single chain, bispecific;
IG single chain scFv-scFv-scFc, anti-MUC17 and anti-CD3E (1-984) [scFv-VH-V-LAMBDA anti-MUC17 (1-242) [VH (Homo sapiens IGHV4-34*01 (91.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.7.14] (26-33.51-57.96-109)) (1-120) -15-mer tris(tetraglycyl-seryl) linker (121-135) -V-LAMBDA (Homo sapiens IGLV3-1*01 (93.7%) -IGLJ2*01 (90.9%) G120>C (234), CDR-IMGT [6.3.9] (161-166.184-186.223-231)) (136-242)] -5-mer tetraglycyl-seryl linker (243-247) -[scFv-VH-V-LAMBDA anti-CD3E (248-496) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (274-280.298-307.346-361)) (248-372) -15-mer tris(tetraglycyl-seryl) linker (373-387) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (413-421.439-441.478-486)) (388-496)] -4-mer tetraglycyl linker (497-500) -[scFc (h-CH2-CH3)-(h-CH2-CH3) (501-984) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (501-510), CH2 R83>C (572), N84.4>G (577), V85>C (582) (511-620), CH3 E12 (636), M14 (638) (621-725), CHS (726-727)) (501-727)] -30-mer hexakis(tetraglycyl-seryl) linker (728-757) -[Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (758-767), CH2 R83>C (829), N84.4>G (834), V85>C (839) (768-877), CH3 E12 (893), M14 (895) (878-982), CHS (983-984)) (758-984)]], produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Структура

Структура Вепситамаб Структура 2 Вепситамаб

Иностранные названия

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