Веренафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2699034-69-8

chimeric immunoglobulin G1-kappa antigen-binding fragment (Fab) anti-[human insulin receptor (INSR)] fused at the C-terminus of the heavy chain via peptide linker ²²¹LSS²²³ to human iduronate-2-sulfatase fragment, glycoform alfa;
gamma 1 heavy chain (1-220) [VH (Mus musculus IGHV1S56*01 - (IGHD) -IGHJ3*01, CDR-Kabat [5.17.4] (31-35.50-66.99-102)) (1-113) -Homo sapiens IGHG1*01 (CH1 (114-211), hinge truncated removing C-terminal TCPPCP (212-220))] fused via peptide linker ²²¹LSS²²³ to human iduronate-2-sulfatase (EC:3.1.6.13, alpha-L- iduronate sulfate sulfatase (idursulfase)) (224-748 in the current sequence, residue 282 posttranslationally modified to formylglycine (fGly)), (216-214') -disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV9- 120*01 -IGKJ1*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'- 97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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