Вибапапоген аутолейцел

Rec. INN (наименование, зарегистрированное ВОЗ)

Autologous peripheral blood mononuclear cells (PBMCs) expressing human papillomavirus types 16 and 18 antigens. Autologous peripheral blood mononuclear cells (PBMCs), specifically B lymphocytes and monocytes that are T-cell depleted, transfected ex vivo with a non-replicating adenoviral vector that expresses a codon-optimised fusion of tumour-associated antigens (TAAs) E6 and E7 derived from human papillomavirus (HPV) types 16 and 18 (HPV-16/18 E6/E7). The antigen coding region is preceded by a tPA signal sequence and transcription is under the control of the cytomegalovirus (CMV)-tetracycline 10 promoter and the SV40 poly(A) termination sequence. The vector genome is flanked by inverted terminal repeats and contains an encapsidation signal and a K35 knob.

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