Виластобарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2760549-50-4

immunoglobulin G1-fused prodomain kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV1-69*08 (84.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, D12, L14, G1v7 CH2 D3, E117 (CH1 K120 (216) (120-217), hinge 1-15 (218-232), CH2 S3>D (241), I117>E (334) (233-342), CH3 D12 (358), L14 (360) (343-447), CHS (448-449)) (120-449)], (222-241')-disulfide with fused prodomain kappa light chain humanized (1'-241') [prodomain (1'-28') fused to V- KAPPA (Homo sapiens IGKV6-21*02 (78.5%) -IGKJ4*01 (100%), CDR-IMGT [5.3.9] (55'-59'.77'-79'.116'-124')) (29'-134') -Homo sapiens IGKC*01, Km3 A45.1 (180'), V101 (218') (135'-241')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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