Винтесомеран

Rec. INN (наименование, зарегистрированное ВОЗ)

2923391-66-4

messenger RNA (mRNA), 5'-capped, encoding a full-length, codon-optimised pre-fusion stabilised conformation variant (K982P and V983P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (Omicron variant XBB.1.16; based upon GISAID: EPI_ISL_16835403) further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human alpha globin gene (HBA1) modified to contain an identification and ratio (IDR) sequence to enable identification and relative ratio determination of individual RNA components in a multivalent mRNA vaccine, and terminated by a 3' polyadenylation (polyA) tail; contains N¹-methylpseudouridine instead of uridine (all-U>m¹Ψ).

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