Висларафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2850355-96-1

human signal regulatory protein alpha (SIRPα) fragment, anti- (human CD47, integrin associated protein (IAP)), fused via a (G₄S)₃ peptide linker to the N-terminus of both light chains of a humanized immunoglobulin G1-kappa anti-(human epidermal growth factor receptor 2), glycoform alfa;
gamma 1 heavy chain (1-450) [VH (Homo sapiens IGHV3-66*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.11] (31-35.50-66.99-109)) (1-120) -Homo sapiens IGHG1*03 (CH1 (121-218), hinge (219-233), CH2 S³⁰¹>A, E³³⁶>A, K³³⁷>A (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-354')- disulfide with human signal regulatory protein alpha (SIRP alpha variant V2 extracellular D1 domain, SIRP alpha V2D1) fragment 31-155, comprising the first two extracellular loops of the D1 domain, [N110>A80]- variant, anti-(human CD47, integrin associated protein (IAP)) (1-125 in the current sequence) fused via a (G₄S)₃peptide linker (126-140) to kappa light chain (141'-354') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ1*01, CDR-Kabat [11.7.9] (164'-174'.190'-196'.229'-237')) (141'-247') -Homo sapiens IGKC*01 (248'-354')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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