Висугромаб
VisugromabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2556646-63-8
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens GDF15 (growth differentiation factor 15, PLAB, MIC-1, PDF, MIC1, NAG-1, PTGFB)], monoclonal antibody;
gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV2-5*02 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [10.7.10] (26-35.53-59.98-107)) (1-118) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (119-216), hinge 1-12 S10>P (226) (217-228), CH2 (229-338), CH3 (339-443), CHS K2>del (444)) (119-444)], (201-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-15*01 (82.1%) -IGKJ2*01 (100%)/Homo sapiens IGKV1-9*01 (76.8%) -IGKJ2*01 (91.7%) Q120>G (100), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV2-5*02 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [10.7.10] (26-35.53-59.98-107)) (1-118) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (119-216), hinge 1-12 S10>P (226) (217-228), CH2 (229-338), CH3 (339-443), CHS K2>del (444)) (119-444)], (201-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-15*01 (82.1%) -IGKJ2*01 (100%)/Homo sapiens IGKV1-9*01 (76.8%) -IGKJ2*01 (91.7%) Q120>G (100), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Структура
Иностранные названия
- Visugromabum (латинское)
- Visugromab (английское)
- Visugromab (немецкое)
- Visugromab (французское)
- Visugromab (испанское)
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