Викстимотамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2243775-32-6

immunoglobulin V-kappa-VH-V-lambda-VH' chain homodimer, anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)] and anti-[Homo sapiens CD33 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67)], monoclonal antibody V-kappa-VH-V-lambda-VH' chain noncovalent homodimer, bispecific, tetravalent;
IG V-kappa-VH-V-lambda-VH' chain anti-CD3E and anti-CD33 (1-483) [anti-CD3E V-KAPPA (Homo sapiens IGKV1-17*01 (72.5%) -IGKJ1*01 (91.7%)) CDR-IMGT [9.3.9] (27-35.53-55.92-100) (1-110)] -6-mer bis(diglycyl-seryl) linker (111-116) -anti-CD33 VH (Homo sapiens IGHV1-8*01 (94.9%) -(IGHD) -IGHJ1*01 (100%)) CDR-IMGT [8.8.15] (142-149.167-174.213-227) (117-238) -4-mer diglycyl-seryl-glycyl linker (239-242) -anti-CD33 V-LAMBDA (Homo sapiens IGLV1-44*01 (95.9%) -IGLJ3*01 (86.7%)) CDR-IMGT [8.3.11] (268-275.293-295.332-342) (243-352)] -6-mer bis(diglycyl-seryl) linker (353-358) -anti-CD3E VH (Mus musculus IGHV10-1*02 (89.8%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-72*01 (88.0%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.10.16] (384-391.409-418.457-472) (359-483)]; noncovalent homodimer, produced in a Chinese hamster ovary (CHO)-derived cell line, non-glycosylated

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