Вобрамитамаб дуокармазин
Vobramitamab duocarmazineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2490556-51-7
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD276 (B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3)], humanized monoclonal antibody, conjugated to the pro-drug seco-duocarmycin-p-hydroxybenzamide-azaindole (seco-DUBA) via a linker;
gamma1 heavy chain humanized (1-447) [VH (Homo sapiens IGHV3-7*01 (89.8%) -(IGHD) -IGHJ6*01 (92.9%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (118-447)], (220-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa, conjugated on an average of 2.7 cysteines, to seco-DUBA via the cleavable linker N-[2-(2-maleimidoethoxy)ethoxycarbonyl]-l-valyl-l-citrullyl-p-aminobenzyloxycarbonyl-N-[2-(2-hydroxyethoxy)ethyl]-N-[2-(methylamino)ethyl]carbamoyl
gamma1 heavy chain humanized (1-447) [VH (Homo sapiens IGHV3-7*01 (89.8%) -(IGHD) -IGHJ6*01 (92.9%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (118-447)], (220-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa, conjugated on an average of 2.7 cysteines, to seco-DUBA via the cleavable linker N-[2-(2-maleimidoethoxy)ethoxycarbonyl]-l-valyl-l-citrullyl-p-aminobenzyloxycarbonyl-N-[2-(2-hydroxyethoxy)ethyl]-N-[2-(methylamino)ethyl]carbamoyl
Структура
Иностранные названия
- Vobramitamabum duocarmazinum (латинское)
- Vobramitamab duocarmazine (английское)
- Vobramitamab duocarmazin (немецкое)
- Vobramitamab duocarmazine (французское)
- Vobramitamab duocarmazina (испанское)
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