Воксалатамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2411871-58-2

immunoglobulin G4-kappa/lambda2, anti-[Homo sapiens FOLH1 (folate hydrolase, prostate specific membrane antigen, PSMA)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], humanized, chimeric and Homo sapiens monoclonal antibody, bispecific;
gamma4 heavy chain humanized anti-FOLH1 (1-451) [VH anti-FOLH1 (Homo sapiens IGHV3-23*01 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (125-222), hinge 1-12 S10>P (232) (223-234), CH2 F1.3>A (238), L1.2>A (239) (235-344), CH3 (345-449), CHS (450-451)) (125-451)], (138-214')-disulfide with kappa light chain Homo sapiens anti-FOLH1 (1'-214') [V-KAPPA anti-FOLH1 (Homo sapiens IGKV3-11*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
gamma4 heavy chain chimeric anti-CD3E (1''-452'') [VH anti-CD3E Musmus/Homsap (Mus musculus IGHV10-1*02 (89.8%) -(IGHD) -IGHJ3*01 (93.3%) A128>S (125)/Homo sapiens IGHV3-72*01 (88.0%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (120), CDR-IMGT [8.10.16] (26-33.51-60.99-114)) (1''-125'') -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (126''-223''), hinge 1-12 S10>P (233) (224''-235''), CH2 F1.3>A (239), L1.2>A (240) (236''-345''), CH3 F85.1>L (410) (346''-450''), CHS (451''-452'')) (126''-452'')], (139''-214''')-disulfide with lambda2 light chain humanized anti-CD3E (1'''-215''') [V-LAMBDA anti-CD3E (Homo sapiens IGLV7-43*01 (81.9%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (26-34.52-54.91-99)), (1'''-109''') -Homo sapiens IGLC2*01 (100%) (110'''-215''')]; dimer (230-231'':233-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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